TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8⁺ T cells.

ABSTRACT: T cell activation is dependent upon the integration of antigenic, co-stimulatory and cytokine-derived signals and the availability and acquisition of nutrients from the environment. Furthermore, T cell activation is accompanied by reprogramming of cellular metabolism to provide the energy and building blocks for proliferation, differentiation and effector function. Transforming growth factor β (TGFβ) has pleiotropic effects on T cell populations, having both an essential role in the maintenance of immune tolerance but also context-dependent pro-inflammatory functions. We set out to define the mechanisms underpinning the suppressive effects of TGFβ on mouse CD8⁺ T cell activation. RNA-sequencing analysis of TCR-stimulated T cells determined that Myc-regulated genes were highly en

SUBMITTER: Hope HC 

PROVIDER: S-EPMC9360539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature