Frequency-dependent characteristics of nerve-mediated ATP and acetylcholine release from detrusor smooth muscle.

ABSTRACT:

New findings

What is the central question of this study? Is the frequency dependence of co-transmitter release from postganglionic nerve fibres different for each transmitter? What is the main finding and its importance? Release of co-transmitters from the parasympathetic supply to detrusor smooth muscle can be independently regulated. This offers a targeted drug model to reduce selectively the release of transmitter associated with human pathologies (ATP) and may also be applicable to other smooth muscle-based disorders of visceral tissues.

Abstract

Nerve-mediated contractions of detrusor smooth muscle are mediated by acetylcholine (ACh) and ATP release in most animals. However, with the normal human bladder, only ACh is a functional transmitter, but in benign pathologies s

SUBMITTER: Chakrabarty B 

PROVIDER: S-EPMC9360561 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature