Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study.

ABSTRACT: Background and Aims: Epidemiological studies have suggested positive associations between asthma and the risk of cardiovascular diseases (CVDs). However, causality remains inconclusive. We aim to explore the causal associations between asthma and CVDs risk using the Mendelian Randomization (MR) approach. Methods: We obtained summary-level data for eight CVDs [including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), stroke, ischemic stroke, large artery stroke, small vessel stroke, and cardioembolic stroke] from several large genome-wide association studies (GWASs) and the FinnGen consortium. Nine lead single-nucleotide polymorphisms associated with asthma (p < 5 × 10^-8) were identified from the GWAS conducted by the Trans-Nation

SUBMITTER: Chen H 

PROVIDER: S-EPMC9360591 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature