Cold atmospheric plasma induces apoptosis in human colon and lung cancer cells through modulating mitochondrial pathway.

ABSTRACT: Cold atmospheric plasma (CAP) is an emerging and promising oncotherapy with considerable potential and advantages that traditional treatment modalities lack. The objective of this study was to investigate the effect and mechanism of plasma-inhibited proliferation and plasma-induced apoptosis on human lung cancer and colon cancer cells in vitro and in vivo. Piezobrush^® PZ2, a handheld CAP unit based on the piezoelectric direct discharge technology, was used to generate and deliver non-thermal plasma. Firstly, CAP_PZ2 treatment inhibited the proliferation of HT29 colorectal cancer cells and A549 lung cancer cells using CCK8 assay, caused morphological changes at the cellular and subcellular levels using transmission electron microscopy, and suppressed both

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9360593 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature