Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19.

ABSTRACT:

Background

Recruitment into randomized trials of hydroxychloroquine (HCQ) for prevention of COVID-19 has been adversely affected by a widespread conviction that HCQ is not effective for prevention. In the absence of an updated systematic review, we conducted a meta-analysis of randomized trials that study the effectiveness of HCQ to prevent COVID-19.

Methods

A search of PubMed, medRxiv, and clinicaltrials.gov combined with expert consultation found 11 completed randomized trials: 7 pre-exposure prophylaxis trials and 4 post-exposure prophylaxis trials. We obtained or calculated the risk ratio of COVID-19 diagnosis for assignment to HCQ versus no HCQ (either placebo or usual care) for each trial, and then pooled the risk ratio estimates.

Results

The pooled risk ratio e

SUBMITTER: Garcia-Albeniz X 

PROVIDER: S-EPMC9360718 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature