Bioinformatics analysis of lncRNAs in the occurrence and development of osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is a disease with high mortality in children and adolescents, and metastasis is one of its important clinical features. However, the molecular mechanism of OS occurrence is not completely clear. Thus, we screened potential biomarkers of OS and analyze their prognostic value.

Methods

The Cancer Genome Atlas (TCGA) datasets were used to analyze the differential lncRNAs in patients with OS of different immune score and the lncRNAs expressed by immune cells. Cox regression was used to develop the prognosis prediction model and specify the prognosis outcomes. Risk-proportional regression model was constructed, and the samples were divided into high and low groups based on the risk scores for the survival analysis. The areas under the receiver operatin

SUBMITTER: Liu H 

PROVIDER: S-EPMC9360822 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature