An inflammatory response-related gene signature associated with immune status and prognosis of acute myeloid leukemia.

ABSTRACT:

Objective

To determine the prognostic significance of inflammatory response-associated genes in acute myeloid leukemia (AML).

Methods

Transcriptomic profiles and related clinical information of AML patients were acquired from a public database. To establish a multi-gene prognosis signature, we performed least absolute shrinkage and selection operator Cox analysis for the TCGA cohort and evaluated the ICGC cohort for verification. Subsequently, Kaplan-Meier analysis was carried out to compare the overall survival (OS) rates between high- and low-risk groups. Biological function and single-sample gene set enrichment (ssGSEA) analyses were employed to investigate the association of risk score with immune status and the tumor microenvironment. Prognostic gene expression levels i

SUBMITTER: Wu X 

PROVIDER: S-EPMC9360836 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature