Classifying mild cognitive impairment and Alzheimer's disease by constructing a 14-gene diagnostic model.

ABSTRACT:

Background

Alzheimer's disease (AD) and mild cognitive impairment (MCI) are two neurodegenerative diseases. Most patients with MCI will develop AD. Early detection of AD and MCI is a crucial issue in terms of secondary prevention. Therefore, more diagnostic models need to be developed to distinguish AD patients from MCI patients.

Methods

In our research, the expression matrix and were screened from Gene Expression Omnibus (GEO) databases. A 14-gene diagnostic model was constructed with lasso logistic analysis. The efficiency and accuracy of diagnostic model have also been validated. In order to clarify the expression differences of 14 genes in health donor, AD and MCI, the blood samples of patients and healthy individuals were collected. The mRNA expression of the 14 genes i

SUBMITTER: Han J 

PROVIDER: S-EPMC9360837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature