Genomic mutation characteristics and prognosis of biliary tract cancer.

ABSTRACT:

Background

The incidence of biliary system cancer is higher in the Chinese population than in the West. The overall prognosis of gallbladder cancer and cholangiocarcinoma is poor, and the current treatment is limited. In order to explore the pathogenesis of biliary tract cancers and potential targeted therapies, we mapped the mutation landscape of biliary tract cancer in the Chinese population and analyzed the molecular mechanism related to prognosis.

Methods

A total of 59 formalin fixed paraffin-embedded (FFPE) tissue samples were obtained from patients with operable biliary tract cancer. We conducted targeted capture sequencing of 620 genes through high-throughput sequencing technology and analyzed the fusion information of 13 genes.

Results

Mutations were detected

SUBMITTER: Guo L 

PROVIDER: S-EPMC9360853 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature