Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-¹³C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study.

ABSTRACT: Purpose To evaluate glioblastoma (GBM) metabolism by using hyperpolarized carbon 13 (¹³C) MRI to monitor the exchange of the hyperpolarized ¹³C label between injected [1-¹³C]pyruvate and tumor lactate and bicarbonate. Materials and Methods In this prospective study, seven treatment-naive patients (age [mean ± SD], 60 years ± 11; five men) with GBM were imaged at 3 T by using a dual-tuned ¹³C-hydrogen 1 head coil. Hyperpolarized [1-¹³C]pyruvate was injected, and signal was acquired by using a dynamic MRI spiral sequence. Metabolism was assessed within the tumor, in the normal-appearing brain parenchyma (NABP), and in healthy volunteers by using paired or unpaired t tests and a Wilcoxon signed rank test. The Spearman ρ correlation

SUBMITTER: Zaccagna F 

PROVIDER: S-EPMC9360994 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature