Bruton's TK regulates myeloid cell recruitment during acute inflammation.

ABSTRACT:

Background and purpose

Bruton's TK (BTK) is a non-receptor kinase best known for its role in B lymphocyte development that is critical for proliferation and survival of leukaemic cells in B-cell malignancies. However, BTK is expressed in myeloid cells, particularly neutrophils, monocytes and macrophages where its inhibition has been reported to cause anti-inflammatory properties.

Experimental approach

We explored the role of BTK on migration of myeloid cells (neutrophils, monocytes and macrophages), in vitro using chemotaxis assays and in vivo using zymosan-induced peritonitis as model systems.

Key results

Using the zymosan-induced peritonitis model of sterile inflammation, we demonstrated that acute inhibition of BTK prior to zymosan challenge reduced phosphorylation

SUBMITTER: Purvis GSD 

PROVIDER: S-EPMC9361009 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature