Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults.

ABSTRACT:

Importance

Immune-mediated rippling muscle disease (iRMD) is a rare myopathy characterized by wavelike muscle contractions (rippling) and percussion- or stretch-induced muscle mounding. A serological biomarker of this disease is lacking.

Objective

To describe a novel autoantibody biomarker of iRMD and report associated clinicopathological characteristics.

Design, setting, and participants

This retrospective cohort study evaluated archived sera from 10 adult patients at tertiary care centers at the Mayo Clinic, Rochester, Minnesota, and Brigham & Women's Hospital, Boston, Massachusetts, who were diagnosed with iRMD by neuromuscular specialists in 2000 and 2021, based on the presence of electrically silent percussion- or stretch-induced muscle rippling and percussion-in

SUBMITTER: Dubey D 

PROVIDER: S-EPMC9361081 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature