Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci With Childhood Hodgkin Lymphoma.

ABSTRACT:

Importance

Studies focusing on genetic susceptibility of childhood Hodgkin lymphoma (HL) are limited.

Objectives

To identify genetic variants associated with childhood-onset HL vs adult-onset HL.

Design, setting, and participants

This genetic association study was performed with 3 cohorts: the St Jude Lifetime Cohort Study (SJLIFE), initiated in 2007 with ongoing follow-up, and the original and expansion cohorts of the Childhood Cancer Survivor Study (CCSS), initiated in the 1990s with ongoing follow-up. Results of these genome-wide association studies (GWASs) were combined via meta-analysis. Data were analyzed from June 2021 to June 2022.

Main outcomes and measures

Childhood HL was the focused outcome. Single-nucleotide variant (SNV, formerly single-nucleotide

SUBMITTER: Chen C 

PROVIDER: S-EPMC9361085 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature