Assessment of cognitive and psychomotor impairment, subjective effects, and blood THC concentrations following acute administration of oral and vaporized cannabis.

ABSTRACT:

Background

Cannabis legalization is expanding, but there are no established methods for detecting cannabis impairment.

Aim

Characterize the acute impairing effects of oral and vaporized cannabis using various performance tests.

Methods

Participants (N = 20, 10 men/10 women) who were infrequent cannabis users ingested cannabis brownies (0, 10, and 25 mg Δ-9-tetrahydrocannabinol, THC) and inhaled vaporized cannabis (0, 5, and 20 mg THC) in six double-blind outpatient sessions. Cognitive/psychomotor impairment was assessed with a battery of computerized tasks sensitive to cannabis effects, a novel test (the DRiving Under the Influence of Drugs, DRUID^®), and field sobriety tests. Blood THC concentrations and subjective drug effects were evaluated.

Res

SUBMITTER: Spindle TR 

PROVIDER: S-EPMC9361180 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature