Acute nicotine differentially impacts anticipatory valence- and magnitude-related striatal activity.

ABSTRACT:

Background

Dopaminergic activity plays a role in mediating the rewarding aspects of abused drugs, including nicotine. Nicotine modulates the reinforcing properties of other motivational stimuli, yet the mechanisms of this interaction are poorly understood. This study aimed to ascertain the impact of nicotine exposure on neuronal activity associated with reinforcing outcomes in dependent smokers.

Methods

Smokers (n = 28) and control subjects (n = 28) underwent functional imaging during performance of a monetary incentive delay task. Using a randomized, counterbalanced design, smokers completed scanning after placement of a nicotine or placebo patch; nonsmokers were scanned twice without nicotine manipulation. In regions along dopaminergic pathway trajectories, we considered e

SUBMITTER: Rose EJ 

PROVIDER: S-EPMC9361221 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature