Sex-specific transcriptome differences in a middle-aged frailty cohort.

ABSTRACT:

Background

Frailty is a clinical syndrome described as reduced physiological reserve and increased vulnerability. Typically examined in older adults, recent work shows frailty occurs in middle-aged individuals and is associated with increased mortality. Previous investigation of global transcriptome changes in a middle-aged cohort from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study demonstrated inflammatory genes and pathways were significantly altered by frailty status and race. Transcriptome differences in frailty by sex remain unclear. We sought to discover novel genes and pathways associated with sex and frailty in a diverse middle-aged cohort using RNA-Sequencing.

Methods

Differential gene expression and pathway analyses were perform

SUBMITTER: Pacheco NL 

PROVIDER: S-EPMC9361278 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature