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Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids.

ABSTRACT: In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic acids is described. It utilizes the photocatalytic activation of (cyano)azaarenes in the presence of fac-Ir(ppy)₃ as a photocatalyst. The methodology is versatile and provides access to biologically relevant 4-substituted-chroman-2-ones. Visible light, photoredox catalyst, base, anhydrous solvent, and inert atmosphere constitute key parameters for the success of the described strategy. The developed methodology involves a wide range of coumarin-3-carboxylic acids as well as (cyano)azaarenes.

SUBMITTER: Kowalska E

PROVIDER: S-EPMC9361294 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids.

Kowalska Ewelina E Artelska Angelika A Albrecht Anna A

The Journal of organic chemistry 20220712 15

In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic acids is described. It utilizes the photocatalytic activation of (cyano)azaarenes in the presence of fac-Ir(ppy)3 as a photocatalyst. The methodology is versatile and provides access to biologically relevant 4-substituted-chroman-2-ones. Visible light, photoredox catalyst, base, anhydrous solvent, and inert atmosphere constitute key parameters for the success of the described strategy. The de ...[more]

PMID: 35820401

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