Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway.

ABSTRACT: A key to improving vaccine design and vaccination strategy is to understand the mechanism behind the variation of vaccine response with host factors. Glycosylation, a critical modulator of immunity, has no clear role in determining vaccine responses. To gain insight into the association between glycosylation and vaccine-induced antibody levels, we profiled the pre- and postvaccination serum protein glycomes of 160 Caucasian adults receiving the FLUZONE influenza vaccine during the 2019-2020 influenza season using lectin microarray technology. We found that prevaccination levels of Lewis A antigen (Le^a) are significantly higher in nonresponders than responders. Glycoproteomic analysis showed that Le^a-bearing proteins are enriched in complement activation pathways, sugg

SUBMITTER: Qin R 

PROVIDER: S-EPMC9361353 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature