Potential Mechanisms of the Sparing of Atopic Dermatitis in the Diaper Region: A Scoping Review.

ABSTRACT: Atopic dermatitis (AD) is a chronic, inflammatory skin condition commonly affecting infants with notable sparing of the diaper region. Though sources anecdotally attribute this sparing to the physical barrier formed by the diaper and the subsequent retention of moisture, urine, sweat and feces, no studies have formally investigated the factors contributing to this sparing phenomenon. We performed a scoping literature review to investigate the factors involved in sparing of AD in the diaper region, namely humidity, scratching, urine, sweat, feces, and microbiome composition. A total of 130 papers met the inclusion criteria, and extracted data were analyzed in an iterative manner. Increased local humidity facilitates protective changes at the cellular level and offsets transepidermal water l

SUBMITTER: Jazdarehee A 

PROVIDER: S-EPMC9361425 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature