Predictive value of proteomic markers for advanced rectal cancer with neoadjuvant chemoradiotherapy.

ABSTRACT:

Background

Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect to prognosis and response to nCRT are needed due to the diverse response to the therapy.

Methods

Thirteen paired pre- and post-nCRT sera from rectal cancer patients were analyzed by isobaric tags for relative and absolute quantitation (iTRAQ) method. Twenty-five proteins were selected for validation by parallel reaction monitoring (PRM) in ninety-one patients.

Results

Totally, 310 proteins were identified and quantified in sera samples. Reactome pathway analysis showed that the immune activation-related pathways were enriched in response to nCRT. Twenty-five proteins were selected for further v

SUBMITTER: Wang H 

PROVIDER: S-EPMC9361520 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature