The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma.

ABSTRACT:

Background

Standard treatment of soft tissue sarcoma (STS) of the extremities includes limb-sparing surgery combined with pre- or postoperative radiotherapy (RT). The role of perioperative chemotherapy (CTX) remains uncertain. STS patients with high-risk features for local recurrence, distant metastases, and increased mortality may require additional systemic therapy. The objective of this study was to evaluate predictors of outcome regarding local control (LC), overall survival (OS), and freedom from distant metastases (FFDM) in a large single-center cohort of patients suffering from localized high-grade STS (grade 2/3, G2/G3). Special emphasis was put on a subgroup of patients who received combined neoadjuvant radiochemotherapy (RCT).

Methods

Overall, 115 adult STS patient

SUBMITTER: Kobus M 

PROVIDER: S-EPMC9361547 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature