High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth.

ABSTRACT:

Background

Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use. Here, based on our previous study of sterol O-acyltransferase 1 (SOAT1) in hepatocelluar carcinoma, we sought to screen an effective targeted drug for precise treatment of hepatocelluar carcinoma and, from the perspective of cholesterol metabolism, clarify the relationship between cholesterol regulation and tumorigenesis and development.

Methods

In this study, we developed a virtual screening integrated affinity screening technology for target protein drug screening. A series of in vitro and in vivo experiments were used for drug activity verification. Multi-omics analysis and flow cytometry analysis were used to exp

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9361549 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature