A simplified CD34+ based preharvest prediction tool for HPC(A) collection.

ABSTRACT:

Background

Hematopoietic stem cell transplantation is an important treatment that is dependent on the collection of sufficient CD34+ hematopoietic progenitor cells. The peripheral blood CD34 count (PB CD34+ counts) measured by flow cytometry can be used in predicting CD34+ stem cell yields hours before the completion of collection. Previously described formulas to predict the yield have used many different variables. As such, there is currently no consensus on an industry-standard algorithm or formula.

Study design and methods

Retrospective reviews of same-day PB CD34+ counts and the ensuing absolute CD34+ yields of mobilized donors (allogeneic and autologous) were used to develop and validate a formula using regression analysis to predict the CD34+ stem cell yield. A metric

SUBMITTER: Jacob RP 

PROVIDER: S-EPMC9361583 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature