The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis.

ABSTRACT: Over 50% of women experience mood disturbance in the postpartum period, with significant implications for maternal and infant health but identifying those at risk is not easily possible. The essential amino acid, tryptophan (TRP) through its neuroactive metabolites, has been implicated in the pathology of mood disorders. Thus, TRP levels tested in the peripartum period have been proposed as a potential biomarker for subsequent development of postpartum mood disturbances, in particular postpartum depression (PPD). A systematic review and meta-analysis following PROSPERO guidelines [CRD42021252462] was conducted on peer-reviewed, English language studies that measured blood levels of TRP during the postpartum period in women who were also evaluated for postpartum "blues" or PPD. Thirteen stu

SUBMITTER: Liu ZF 

PROVIDER: S-EPMC9361669 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature