Genetic Factors of Idiopathic Recurrent Miscarriage in Kazakh Population.

ABSTRACT:

Background

It seems that 50% of the possible causes of recurrent miscarriage do not have any explainable etiology and they require in-depth etiopathogenesis analysis. The purpose of this research was to study polymorphisms relationship of the immune response genes including Val249Ile CX3CR1 (rs3732379), CT60 G/A CTLA4 (rs3087243), and HLA DQA1, DQB1, DRB1 (major histocompatibility complex, class II) with development of idiopathic form of recurrent miscarriage (iRM) in Kazakh population.

Methods

TagMan genotyping for 302 patients with iRM and 300 women with normal reproduction was performed. Molecular genetic studies were carried out by the TaqMan method of unified site-specific amplification and real-time genotyping using test systems. Statistical tests and Chi Square were c

SUBMITTER: Svyatova GS 

PROVIDER: S-EPMC9361729 | biostudies-literature | 2022 Jan-Mar

REPOSITORIES: biostudies-literature