The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging - relevant neural and immune function.

ABSTRACT: Human longevity has a strong familial and genetic component. Dynamic characteristics of the gut microbiome during aging associated with longevity, neural, and immune function remained unknown. Here, we aim to reveal the synergistic changes in gut microbiome associated with decline in neural and immune system with aging and further obtain insights into the establishment of microbiome homeostasis that can benefit human longevity. Based on 16S rRNA and metagenomics sequencing data for 32 longevity families including three generations, centenarians, elderly, and young groups, we found centenarians showed increased diversity of gut microbiota, severely damaged connection among bacteria, depleted in microbial-associated essential amino acid function, and increased abundance of anti-inflammatory

SUBMITTER: Wang J 

PROVIDER: S-EPMC9361766 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature