Impact of the diagnostic delay of acromegaly on bone health: data from a real life and long term follow-up experience.

ABSTRACT:

Introduction

Acromegaly is a chronic disease with systemic complications. Disease onset is insidious and consequently typically burdened by diagnostic delay. A longer diagnostic delay induces more frequently cardiovascular, respiratory, metabolic, neuropsychiatric and musculoskeletal comorbidities. No data are available on the effect of diagnostic delay on skeletal fragility. We aimed to evaluate the effect of diagnostic delay on the frequency of incident and prevalent of vertebral fractures (i-VFs and p-VFs) in a large cohort of acromegaly patients.

Patients and methods

A longitudinal, retrospective and multicenter study was conducted on 172 acromegaly patients.

Results

Median diagnostic delay and duration of follow-up were respectively 10 years (IQR: 6) and 10 years

SUBMITTER: Chiloiro S 

PROVIDER: S-EPMC9362053 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature