An insight into differential protein abundance throughout Leishmania donovani promastigote growth and differentiation.

ABSTRACT: Leishmania donovani causes anthroponotic visceral leishmaniasis, responsible for about 50,000 annual deaths worldwide. Current therapies have considerable side effects. Drug resistance has been reported and no vaccine is available nowadays. The development of undifferentiated promastigotes in the sand fly vector's gut leads to the promastigote form that is highly infective to the mammalian host. Fully differentiated promastigotes play a crucial role in the initial stages of mammalian host infection before internalization in the host phagocytic cell. Therefore, the study of protein levels in the promastigote stage is relevant for disease control, and proteomics analysis is an ideal source of vaccine candidate discovery. This study aims to get insight into the protein levels during the diffe

SUBMITTER: Alcolea PJ 

PROVIDER: S-EPMC9362617 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature