Mapping the network biology of metabolic response to stress in posttraumatic stress disorder and obesity.

ABSTRACT: The co-occurrence of stress-induced posttraumatic stress disorder (PTSD) and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understanding of the pathways connecting stress to PTSD and obesity is focused largely on behavioral mediators alone with little consideration of the biological regulatory mechanisms that underlie their co-occurrence. In this work, we leverage prior knowledge to systematically highlight such bio-behavioral mechanisms and inform on the design of confirmatory pilot studies. We use natural language processing (NLP) to extract documented regulatory interactions

SUBMITTER: Chacko TP 

PROVIDER: S-EPMC9362840 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature