Characterization of wax valving and μPIV analysis of microscale flow in paper-fluidic devices for improved modeling and design.

ABSTRACT: Paper-fluidic devices are a popular platform for point-of-care diagnostics due to their low cost, ease of use, and equipment-free detection of target molecules. They are limited, however, by their lack of sensitivity and inability to incorporate more complex processes, such as nucleic acid amplification or enzymatic signal enhancement. To address these limitations, various valves have previously been implemented in paper-fluidic devices to control fluid obstruction and release. However, incorporation of valves into new devices is a highly iterative, time-intensive process due to limited experimental data describing the microscale flow that drives the biophysical reactions in the assay. In this paper, we tested and modeled different geometries of thermally actuated valves to investigate how

SUBMITTER: Newsham EI 

PROVIDER: S-EPMC9362854 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature