Impact of Acute Uninterrupted Sitting on Cerebrovascular Hemodynamics.

ABSTRACT: Reductions in brain blood flow are associated with reduced cognitive function and cerebrovascular disease. Acute periods of uninterrupted sitting can lead to endothelial dysfunction, namely due to a reduction in shear stress and subsequent reduction in nitric oxide bioavailability. Little is known of the impact of sitting on brain health. The purpose was to determine the total brain blood flow response following a 60-minute bout of uninterrupted sitting. Using a parallel design, this study evaluated the impact of 60-minutes of sitting on total brain blood flow. Fifteen participants (n=15; age=24 ± 1yr; BMI=25 ± 1 kg/m²) sat, uninterrupted, for 60-minutes during the SIT protocol. To ascertain the contribution of blood pooling effects on total brain blood flow, ten particip

SUBMITTER: Jones R 

PROVIDER: S-EPMC9362887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature