Extrathymic Aire-expressing cells support maternal-fetal tolerance.

ABSTRACT: Healthy pregnancy requires tolerance to fetal alloantigens as well as syngeneic embryonic and placental antigens. Given the importance of the autoimmune regulator (Aire) gene in self-tolerance, we investigated the role of Aire-expressing cells in maternal-fetal tolerance. We report that maternal ablation of Aire-expressing (Aire ⁺) cells during early mouse pregnancy caused intrauterine growth restriction (IUGR) in both allogeneic and syngeneic pregnancies. This phenotype is immune mediated, as IUGR was rescued in Rag1-deficient mice, and involved a memory response, demonstrated by recurrence of severe IUGR in second pregnancies. Single-cell RNA sequencing demonstrated that Aire ⁺ cell depletion in pregnancy results in expansion of ac

SUBMITTER: Gillis-Buck E 

PROVIDER: S-EPMC9363019 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature