Diagnostic Role of NT-proBNP in Patients with Cardiac Amyloidosis Involvement: A Meta-Analysis.

ABSTRACT:

Background

Amyloidosis is defined as a disorder characterized by the deposition of extracellular protein material of amyloid in tissues.

Objectives

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used to predict the cardiac amyloidosis (CA), but its diagnostic effect on CA involvement remains unclear, especially in terms of specificity and sensitivity.

Methods

A search for literature was conducted in the Pubmed, Embase, and Cochrane library databases, and QUADAS 2 was used for quality assessment. Midas command in Stata 12.0 was used to analyze the subject indicators. Cochran's Q and I2were to test for heterogeneity, and the significant heterogeneity was set at p < 0.05 and/or I2> 50%. Spearman correlation analysis was used to evaluate the threshold effect, an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9363055 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature