Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data.

ABSTRACT: The human circadian pacemaker entrains to the 24-h day, but interindividual differences in properties of the pacemaker, such as intrinsic period, affect chronotype and mediate responses to challenges to the circadian system, such as shift work and jet lag, and the efficacy of therapeutic interventions such as light therapy. Robust characterization of circadian properties requires desynchronization of the circadian system from the rest-activity cycle, and these forced desynchrony protocols are very time and resource intensive. However, circadian protocols designed to derive the relationship between light intensity and phase shift, which is inherently affected by intrinsic period, may be applied more broadly. To exploit this relationship, we applied a mathematical model of the human circadia

SUBMITTER: Stack N 

PROVIDER: S-EPMC9363110 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature