Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.

ABSTRACT:

Introduction

The typical symptoms of Alzheimer's disease (AD) are cognitive impairment, disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor deficits. Neuropathologically, AD is characterized by deposits of pathological forms of endogenous proteins - amyloid-β, and neurofibrillary tau protein pathology. The latter closely correlates with brain atrophy and clinical impairment. Pharmacological therapies for these pathologies are largely absent, raising the question whether non-pharmacological interventions could be efficacious. Environmental factors can play a role in the manifestation of AD. It is unknown whether enriched environment (EE) can ameliorate the propagation of protein aggregates or their toxic components.

Methods

We injected ins

SUBMITTER: Mate V 

PROVIDER: S-EPMC9363241 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature