Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.

ABSTRACT:

Objectives

This study (1) describes and compares saccade and pupil abnormalities in patients with manifest alpha-synucleinopathies (αSYN: Parkinson's disease (PD), Multiple System Atrophy (MSA)) and a tauopathy (progressive supranuclear palsy (PSP)); (2) determines whether patients with rapid-eye-movement sleep behaviour disorder (RBD), a prodromal stage of αSYN, already have abnormal responses that may indicate a risk for developing PD or MSA.

Methods

Ninety (46 RBD, 27 PD, 17 MSA) patients with an αSYN, 10 PSP patients, and 132 healthy age-matched controls (CTRL) were examined with a 10-min video-based eye-tracking task (Free Viewing). Participants were free to look anywhere on the screen while saccade and pupil behaviours were measured.

Results

PD, MSA, and PSP spe

SUBMITTER: Habibi M 

PROVIDER: S-EPMC9363304 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature