Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health.

ABSTRACT:

Purpose of review

Maternal tobacco smoking during pregnancy is of public health concern, and understanding the biological mechanisms can help to promote smoking cessation campaigns. This non-systematic review focuses on the effects of maternal smoking during pregnancy on offspring's epigenome, consistent in chemical modifications of the genome that regulate gene expression.

Recent findings

Recent meta-analyses of epigenome-wide association studies have shown that maternal smoking during pregnancy is consistently associated with offspring's DNA methylation changes, both in the placenta and blood. These studies indicate that effects on blood DNA methylation can persist for years, and that the longer the duration of the exposure and the higher the dose, the larger the effects.

SUBMITTER: Cosin-Tomas M 

PROVIDER: S-EPMC9363403 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature