Ontology highlight
ABSTRACT:
SUBMITTER: Edwards-Hicks J
PROVIDER: S-EPMC9363429 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Edwards-Hicks Joy J Su Huizhong H Mangolini Maurizio M Yoneten Kubra K KK Wills Jimi J Rodriguez-Blanco Giovanny G Young Christine C Cho Kevin K Barker Heather H Muir Morwenna M Guerrieri Ania Naila AN Li Xue-Feng XF White Rachel R Manasterski Piotr P Mandrou Elena E Wills Karen K Chen Jingyu J Abraham Emily E Sateri Kianoosh K Qian Bin-Zhi BZ Bankhead Peter P Arends Mark M Gammoh Noor N von Kriegsheim Alex A Patti Gary J GJ Sims Andrew H AH Acosta Juan Carlos JC Brunton Valerie V Kranc Kamil R KR Christophorou Maria M Pearce Erika L EL Ringshausen Ingo I Finch Andrew J AJ
Nature communications 20220809 1
The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sensitisation to apoptosis may be due to imbalance of metabolic/energetic supply and demand. Here we show that MYC elevates global transcription and translation, even in the absence of glutamine, revealin ...[more]