The crystal structure of Cry78Aa from Bacillus thuringiensis provides insights into its insecticidal activity.

ABSTRACT: Genetically modified plants with insecticidal proteins from Bacillus thuringiensis (Bt) have been successfully utilized to control various kinds of pests in crop production and reduce the abuse of pesticides. However, a limited number of genes are available for the protection of crops from rice planthopper. Recently, Cry78Aa protein from Bt strain C9F1 has been found to have high insecticidal activity against Laodelphax striatellus and Nilaparvata lugens. It is the first reported single-component protein in the world to combat rice planthoppers, making it very promising for use in transgenic crops. The ambiguous mechanism of Cry78Aa functions prevented further engineering or application. Here, we report the crystal structure of Cry78Aa, which consists of two domains: a C-terminal β-pore fo

SUBMITTER: Cao B 

PROVIDER: S-EPMC9363482 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature