Enhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancer.

ABSTRACT: Although the value of tumor-infiltrating lymphocytes is well known, the clinical relevance of an increased immune response, specifically in breast cancer, has not been investigated across large cohorts of patients using computational algorithms. Our hypothesis stated that an enhanced immune response is associated with an improvement in outcomes. To quantify the immune response, we utilized the allograft rejection score correlated with cytolytic activity and with all the other Hallmark immune-related gene sets. The score reflected the amount of infiltrating immune cells that correlated with the immune checkpoint molecule expressions, including CD4⁺ and CD8⁺ T cells, T helper type 1 (Th1) and type 2 (Th2) cells, M1 macrophages, B cells, and plasmacytoid dendritic cells

SUBMITTER: Oshi M 

PROVIDER: S-EPMC9363489 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature