Evaluation of the immune feature of ACPA-negative rheumatoid arthritis and the clinical value of matrix metalloproteinase-3.

ABSTRACT: Anti-citrullinated protein antibodies (ACPAs) are highly specific for the diagnosis of rheumatoid arthritis (RA). However, about one-third of RA patients are negative for ACPAs, which presents a challenge to the early diagnosis of RA. The purpose of this study was to analyze differences in lymphocyte subsets and CD4⁺ T cell subsets between ACPA⁺ and ACPA^- RA patients, and to evaluate the value of matrix metalloproteinase-3 (MMP-3) as a diagnostic and monitoring marker in ACA^- RA patients. A total of 145 ACPA⁺ RA patients, 145 ACPA^- RA patients, and 38 healthy controls (HCs) were included in this study. Peripheral lymphocyte subsets were detected using flow cytometry, and serum MMP-3 was detected using chemiluminescence. Info

SUBMITTER: Liang Z 

PROVIDER: S-EPMC9363571 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature