Prevalence and prognosis of molecularly defined familial hypercholesterolemia in patients with acute coronary syndrome.

ABSTRACT:

Background

Familial hypercholesterolemia (FH) can elevate serum low-density lipoprotein cholesterol (LDL-C) levels, which can promote the progression of acute coronary syndrome (ACS). However, the effect of FH on the prognosis of ACS remains unclear.

Methods

In this prospective cohort study, 223 patients with ACS having LDL-C ≥ 135.3 mg/dL (3.5 mmol/L) were enrolled and screened for FH using a multiple-gene FH panel. The diagnosis of FH was defined according to the ACMG/AMP criteria as carrying pathogenic or likely pathogenic variants. The clinical features of FH and the relationship of FH to the average 16.6-month risk of cardiovascular events (CVEs) were assessed.

Results

The prevalence of molecularly defined FH in enrolled patients was 26.9%, and coronary artery le

SUBMITTER: Wang C 

PROVIDER: S-EPMC9363594 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature