Necroptosis throws novel insights on patient classification and treatment strategies for hepatocellular carcinoma.

ABSTRACT:

Introduction

Necroptosis is a novel pattern of immunogenic cell death and has triggered an emerging wave in antitumor therapy. More evidence has suggested the potential associations between necroptosis and intra-tumoral heterogeneity. Currently, the underlying role of necroptosis remains elusive in hepatocellular carcinoma (HCC) at antitumor immunity and inter-tumoral heterogeneity.

Methods

This study enrolled a total of 728 HCC patients and 139 immunotherapy patients from eight public datasets. The consensus clustering approach was employed to depict tumor heterogeneity of cancer necroptosis. Subsequently, our study further decoded the heterogeneous clinical outcomes, genomic landscape, biological behaviors, and immune characteristics in necroptosis subtypes. For each patie

SUBMITTER: Hu B 

PROVIDER: S-EPMC9363630 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature