In rheumatoid arthritis inflamed joints share dominant patient-specific B-cell clones.

ABSTRACT:

Background

In patients with rheumatoid arthritis (RA) different joints were shown to share the same dominant T-cell clones, suggesting shared characteristics of the inflammatory process and indicating that strategies to selectively target the antigen receptor might be feasible. Since T- and B-lymphocytes closely interact in adaptive responses, we analysed to what extent different joints also share dominant B-cell clones.

Methods

In 11 RA patients, quantitative B-cell receptor (BCR) repertoire analysis was performed in simultaneously obtained samples from inflamed synovial tissue (ST) from distinct locations within one joint, from multiple joints, from synovial fluid (SF) and peripheral blood (PB).

Results

ST biopsies from different locations in the same joint showed c

SUBMITTER: Musters A 

PROVIDER: S-EPMC9363889 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature