ANP32E contributes to gastric cancer progression via NUF2 upregulation.

ABSTRACT: Acidic nuclear phosphoprotein 32 family member E (ANP32E) is a histone chaperone that removes H2A.Z from chromatin. ANP32E is implicated in numerous cellular processes, including cell proliferation, apoptosis and cell differentiation. Increasing evidence suggests that dysregulation of ANP32E expression is strongly associated with carcinogenesis. However, the relationship between ANP32E in the development of gastric cancer (GC) is unknown. The present study aimed to explore the potential role of ANP32E in the development of GC using gain‑of‑function, loss‑of‑function, CCK‑8, colony formation, apoptosis, reverse transcription‑quantitative PCR, immunoblotting and luciferase reporter assay. The results of the present study demonstrated that ANP32E expression levels were significantly increased

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9364136 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature