Effectiveness of treatment for 31 patients with seropositive autoimmune autonomic ganglionopathy in Japan.

ABSTRACT:

Background

Autoimmune autonomic ganglionopathy (AAG) is characterized by serum autoantibodies against the ganglionic acetylcholine receptor (gAChR). Immunomodulatory treatments may alleviate AAG symptoms, but the most appropriate treatment strategy is unclear.

Objective

This study aimed to confirm the effectiveness of treatments, particularly immunotherapy, in patients with seropositive AAG in Japan, as well as to determine the most effective treatment and the best assessment method for clinical response to treatment.

Methods

We collected data from a previous cohort study of patients with seropositive AAG. The clinical autonomic and extra-autonomic symptoms were objectively counted and subjectively assessed using the modified Composite Autonomic Symptom Score. Post-tr

SUBMITTER: Hayashi T 

PROVIDER: S-EPMC9364197 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature