A ratiometric fluorescent sensor for detection of metformin based on terbium-1,10-phenanthroline-nitrogen-doped-graphene quantum dots.

ABSTRACT: Metformin (MTF), an effective biguanide and oral antihyperglycemic agent, is utilized to control blood glucose levels in patients with type II diabetes mellitus, and the determination of its concentration in biological fluids is one of the main issues in pharmacology and medicine. In this work, highly luminescent nitrogen-doped graphene quantum dots (N-GQDs) were modified using terbium (Tb³⁺)-1,10-phenanthroline (Phen) nanoparticles (NPs) to develop a dual-emission ratiometric fluorescent sensor for the determination of MTF in biological samples. The synthesized N-GQDs/Tb-Phen NPs were characterized using different techniques to confirm their physicochemical properties. The N-GQDs/Tb-Phen NPs showed two characteristic emission peaks at 450 nm and 630 nm by exciting at 340 nm tha

SUBMITTER: Gazizadeh M 

PROVIDER: S-EPMC9364225 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature