Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with ¹⁸F-FDG PET/CT: A Single-Center Prospective Study.

ABSTRACT: The aim of this phase II clinical trial (NCT02965001) was to evaluate the prognostic value of urokinase-type plasminogen activator receptor (uPAR) PET/CT with the novel ligand ⁶⁸Ga-NOTA-AE105 in head and neck cancer and compare it with ¹⁸F-FDG. Methods: Patients with head and neck squamous cell carcinoma referred for curatively intended radiotherapy were eligible and prospectively included in this study. ⁶⁸Ga-uPAR and ¹⁸F-FDG PET/CT were performed before initiation of curatively intended radiotherapy, and the SUV_max of the primary tumor was measured on both PET/CT studies by 2 independent readers. Relapse-free survival (RFS) and overall survival (OS) were calculated, and optimal cutoffs were established for ⁶⁸Ga-uPAR

SUBMITTER: Risor LM 

PROVIDER: S-EPMC9364350 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature