Deep learning models for RNA secondary structure prediction (probably) do not generalize across families.

ABSTRACT:

Motivation

The secondary structure of RNA is of importance to its function. Over the last few years, several papers attempted to use machine learning to improve de novo RNA secondary structure prediction. Many of these papers report impressive results for intra-family predictions but seldom address the much more difficult (and practical) inter-family problem.

Results

We demonstrate that it is nearly trivial with convolutional neural networks to generate pseudo-free energy changes, modelled after structure mapping data that improve the accuracy of structure prediction for intra-family cases. We propose a more rigorous method for inter-family cross-validation that can be used to assess the performance of learning-based models. Using this method, we further demonstrate that int

SUBMITTER: Szikszai M 

PROVIDER: S-EPMC9364374 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature