Random field modeling of multi-trait multi-locus association for detecting methylation quantitative trait loci.

ABSTRACT:

Motivation

CpG sites within the same genomic region often share similar methylation patterns and tend to be co-regulated by multiple genetic variants that may interact with one another.

Results

We propose a multi-trait methylation random field (multi-MRF) method to evaluate the joint association between a set of CpG sites and a set of genetic variants. The proposed method has several advantages. First, it is a multi-trait method that allows flexible correlation structures between neighboring CpG sites (e.g. distance-based correlation). Second, it is also a multi-locus method that integrates the effect of multiple common and rare genetic variants. Third, it models the methylation traits with a beta distribution to characterize their bimodal and interval properties. Through si

SUBMITTER: Lyu C 

PROVIDER: S-EPMC9364381 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature